Cell Mediated Lympholysis in Man. The Impact of HLA‐C Antigens
- 1 May 1976
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 7 (5), 301-309
- https://doi.org/10.1111/j.1399-0039.1976.tb01071.x
Abstract
From a population of individuals, all HLA-A, B, and C tissue typed in relation to the Sixth International Histocompatibility Workshop, an experimental investigation has been performed to study the influence of the HLA-Cw1, w2, w3, w4, and w5 antigens in the Cell Mediated Lympholysis (CML) test. The average cytolysis obtained due to allogenic attack of one HLA-C antigen equals 12.6%, but like the HLA-A and B antigens, HLA-C antigens exhibit differences with regard to sensitizing and target potential. This indicates either a heterogeneity of these antigens or the existence of separate CML determinants. It is concluded that the HLA-C antigens may account for the cytolysis observed in some of the combinations exhibiting cytolysis which cannot be explained by the HLA-A and B antigens.This publication has 10 references indexed in Scilit:
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