Delay in the Development of the Allergic Response to Metals Following Intratracheal Instillation

Abstract

Intratracheal intubation with the soluble metal salts potassium dichromate (K₂Cr₂O₇) and nickel sulphate (NiSO₄) causes a delay of up to 8 weeks in the development of delayed hypersensitivity to the specific agent. It is suggested that absorption of sensitizers by the respiratory route may, under certain circumstances, induce a state of specific immunological unresponsiveness, rather than necessarily lead to the development of a state of allergic sensitivity.