Class-Specific Antibody Response to Pneumococcal Capsular Polysaccharides in Men Infected with Human Immunodeficiency Virus Type 1

Abstract

We characterized the effect of infection with human immunodeficiency virus type 1(HIV) on levels of total immunoglobulins and pneumococcal vaccine-specific immunoglobulins in 28 heterosexual and 25 homosexual men seronegative for HIV; 27 asymptomatic, seropositive homosexual men; and 21 patients with AIDS. Total serum IgG levels were increased in both HIV-seropositive groups compared with the HIV-seronegative men (P < .001). Total IgM levels,however, were elevated only in the asymptomatic, HIV-seropositive men (P < .08); total IgA levels were elevated only in the patients with AIDS (P < .05). Vaccine-specific serum IgG, IgM, and IgA significantly increased over baseline three and six weeks after immunization in all groups (P < .05). Responses to vaccine among the HIV-seronegative groups were similar but were greater for all antibody classes than were responses among the HIV-seropositive groups (P < .05).