Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.
Open Access
- 1 October 1976
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 3 (5), 849-855
- https://doi.org/10.1111/j.1365-2125.1976.tb00637.x
Abstract
Isoprenaline dose-response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta-adrenoceptor sites. Phenylephrine dose-response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha-adrenoceptor sites. The ratio of alpha:beta-adrenoceptor antagonism induced by labetalol is approximately 1:3. Peak pharmacological responses after a single oral dose of labetalol (400 mg) occurred between 90-120 min after administration.Keywords
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