Attenuation of the ?-butyrolactone-induced increase in DOPA accumulation by chronic ethanol administration
- 1 September 1979
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 46 (3), 195-204
- https://doi.org/10.1007/bf01250785
Abstract
Summary The effect of γ-butyrolactone (GBL) on the accumulation of dopa after inhibition of aromatic amino acid decarboxylase was studied in rats following chronic treatment with ethanol. The GBL-induced dopa accumulation was significantly decreased in ethanol-treated rats. With the increased duration of the ethanol treatment this effect appears to be more marked in the limbic forebrain. It is suggested that chronic ethanol treatment may produce a decreased sensitivity of central GABA receptors.Keywords
This publication has 28 references indexed in Scilit:
- Dopaminergic neurons: Role of presynaptic receptors in the regulation of transmitter biosynthesisProgress in Neuro-Psychopharmacology, 1978
- Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol AdministrationActa Pharmacologica et Toxicologica, 1978
- Noradrenaline receptor sensitivity after chronic ethanol administrationJournal of Neural Transmission, 1978
- A Procedure for the Isolation of Noradrenaline (together with Adrenaline), Dopamine, 5‐Hydroxytryptamine and Histamine from the Same Tissue Sample Using a Single Column of Strongly Acidic Cation Exchange ResinActa Pharmacologica et Toxicologica, 1978
- Interaction of haloperidol and ?-butyrolactone with (+)-amphetamine-induced changes in monoamine synthesis and metabolism in rat brainJournal of Neural Transmission, 1977
- THE GAMMA‐AMINOBUTYRIC ACID (GABA) SYSTEM IN BRAIN DURING ACUTE AND CHRONIC ETHANOL INTOXICATIONJournal of Neurochemistry, 1975
- Effects of acute and chronic ethanol on the γ-aminobutyric acid system in rat brainBiochemical Pharmacology, 1973
- Alcohol and Presynaptic Inhibition in an Isolated Spinal Cord PreparationArchives of Neurology, 1973
- Effect of anesthetic doses of γ-hydroxybutyrate on subcortical concentrations of homovanillic acidEuropean Journal of Pharmacology, 1971
- γ-Butyrolactone and γ-hydroxybutyric acid—IBiochemical Pharmacology, 1966