Indolmycin Inhibits Prokaryotic Tryptophanyl-tRNA Ligase
- 1 September 1976
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 68 (1), 1-3
- https://doi.org/10.1111/j.1432-1033.1976.tb10758.x
Abstract
Indolmycin specifically prevents the formation of tryptophanyl-tRNA in a prokaryotic system in vitro using Escherichia coli enzymes, but the drug has little effect in an eukaryotic system in vitro (rat liver enzymes). Analysis of the type of inhibition revealed that indolmycin competes with tryptophan as a pure competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase.This publication has 5 references indexed in Scilit:
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