Antagonism of Sulfonamide Inhibition by Para-aminobenzoic Acid and Folic Acid in Toxoplasma Infected Mice

Abstract

Na sulfathiazole when present in the daily diet in concentrations of 1% and 0.15% completely protected 15-to 20-gram mice against fatal dosages of Toxoplasma (R. H. strain). The addition of equal dosages of p-aminobenzoic acid or folic acid to the diet completely inhibited the protective action of the sulfathiazole.