The in Vitro Radiobiology of Astatine-211 Decay
- 1 January 1986
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 105 (1), 27-36
- https://doi.org/10.2307/3576722
Abstract
Chinese hamster V79 cells in culture were exposed to astatine-211, an .alpha.-particle-emitting radiohalogen. The dose-log survival response was linear with no detectable shoulder. Cells in monolayers had a D0 of 1.0 .mu.Ci/ml. Suspended cells had a D0 of 0.60 .mu.Ci/ml with a cellular uptake of 2.5 fCi/cell; this is equal to approximately 1.5 .alpha.-particle traversals per cell nucleus. The frequencies of chromosome and chromatid breaks were linear with dose, but the number declined rapidly with time. These data are discussed in relation to published .alpha.-particle beam studies and the potential use of 211At in radionuclide therapy.This publication has 8 references indexed in Scilit:
- Cyclotron isotopes and radiopharmaceuticals—XXXV astatine-211The International Journal of Applied Radiation and Isotopes, 1985
- INTRACELLULAR-DISTRIBUTION AND RADIOTOXICITY OF CHROMIUM-51 IN MAMMALIAN-CELLS - AUGER-ELECTRON DOSIMETRY1985
- Cell Killing and Division Delay in Asynchronous and Synchronized HeLa Cells Irradiated with Alpha Particles or X RaysRadiation Research, 1984
- Radiotoxicity of 75 Se and 35 S: Theory and Application to a Cellular ModelRadiation Research, 1980
- Inactivation of Synchronized Chinese Hamster V79 Cells with Charged-Particle Track SegmentsRadiation Research, 1980
- RAPID AND REPRODUCIBLE METHOD FOR THE SEPARATION OF CELLS FROM RADIOACTIVE MEDIA1980
- Influence of Radiation Quality on the Effectiveness of Small Doses for Induction of Reproductive Death and Chromosome Aberrations in Mammalian CellsInternational Journal of Radiation Biology, 1979
- Cell Survival Following Multiple-track Alpha Particle IrradiationInternational Journal of Radiation Biology, 1979