Excretion of Valproic Acid into Semen of Rabbits and Man
- 1 December 1978
- Vol. 19 (6), 541-546
- https://doi.org/10.1111/j.1528-1157.1978.tb05034.x
Abstract
Dipropylacetic acid (VPA, valproic acid; an anticonvulsant) was quantified in plasma and semen from rabbits and man using a new GLC assay. The drug assay is rapid, sensitive and free from interference by VPA metabolites. The .beta. phase half-life of VPA in rabbit after an i.v. dose (50 mg/kg) was 56 .+-. 6 min. The concentration of VPA in rabbit plasma was 17-30 .times. the concentration in rabbit semen. In man, 500 mg doses of the free acid orally resulted in VPA concentrations in plasma 11-17 .times. the concurrent levels in semen. VPA, in concentrations up to 10-3 M, did not influence the motility of rabbit spermatozoa in vitro.Keywords
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