Multiple Mechanisms Underlying the Neuroprotective Effects of Antiepileptic Drugs Against In Vitro Ischemia
- 1 May 2006
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 37 (5), 1319-1326
- https://doi.org/10.1161/01.str.0000217303.22856.38
Abstract
Background and Purpose— The possible neuroprotective effects of classic and new antiepileptic drugs on the electrophysiological changes induced by in vitro ischemia on striatal neurons were investigated. In particular, the aim of the study was to correlate the putative neuroprotective effects with the action of these drugs on fast sodium (Na+) and high-voltage–activated (HVA) calcium (Ca2+) currents. Methods— Extracellular field potentials were recorded from rat corticostriatal brain-slice preparations. In vitro ischemia was delivered by switching to an artificial cerebrospinal fluid solution in which glucose and oxygen were omitted. Na+ and HVA Ca2+ currents were analyzed by whole-cell patch-clamp recordings from acutely isolated rat striatal neurons. Excitatory postsynaptic potential was measured following synaptic stimulation in corticostriatal slices by sharp intracellular microelectrodes. Results— Neuroprotection against in vitro ischemia was observed in slices treated with carbamazepine (CBZ), valpr...Keywords
This publication has 33 references indexed in Scilit:
- Calcium signaling and neuronal vulnerability to ischemia in the striatumCell Calcium, 2004
- The Activity of Antiepileptic Drugs as Histone Deacetylase InhibitorsEpilepsia, 2004
- Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein inductionJournal of Neurochemistry, 2004
- Coactivation of GABA A and GABA B Receptor Results in Neuroprotection During In Vitro IschemiaStroke, 2004
- Anti-epileptic drugs as possible neuroprotectants in cerebral ischemiaBrain Research Reviews, 2003
- Microdialysis Sampling of Carbamazepine, Phenytoin and Phenobarbital in Subcutaneous Extracellular Fluid and Subdural Cerebrospinal Fluid in Humans: An in vitro and in vivo Study of Adsorption to the Sampling DeviceBasic & Clinical Pharmacology & Toxicology, 2002
- Post‐ischaemic long‐term synaptic potentiation in the striatum: a putative mechanism for cell type‐specific vulnerabilityBrain, 2002
- Electrophysiology of Sipatrigine: A Lamotrigine Derivative Exhibiting Neuroprotective EffectsExperimental Neurology, 2000
- Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: Implications for ischemia and Huntington's diseaseAnnals of Neurology, 1998
- Valproic AcidDrugs, 1994