THE EFFECT OF GROWTH AND AGING ON FUNCTIONAL CAPILLARY SUPPLY OF THE RAT-HEART
- 1 January 1982
- journal article
- research article
- Vol. 46 (3), 275-281
Abstract
The functional capillary supply of the rat heart was studied in 4-5, 12 and 24 mo. old rats respectively. The subepicardial capillaries were visualized by cinemicrophotography of the beating heart in open-chest rats. The intercapillary distances under both normoxemic and hypoxemic conditions were directly measured from focused film frames. The difference between normoxemic and hypoxemic values yielded the degree of capillary recruitment. If all the animals are treated as a single group, then the intercapillary distance decreases under hypoxemic conditions from 17.1-16.2 .mu.m which represents an additional recruitment of approximately 11% of capillaries. The degree of recruitment, however, is more pronounced in the youngest age group which is also characterized by shorter intercapillary distances, i.e., higher capillarization than the remaining 2 age groups (P < 0.01). On the other hand, no significant differences between the hearts from 1 and 2 yr old animals was found. These results are discussed and compared with those based on morphometric measurements as well as with previous in vivo data obtained from the younger age groups.This publication has 11 references indexed in Scilit:
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