Antidiuretic effect of perorally administered DDAVP in hydrated humans
- 1 April 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 105 (4), 474-476
- https://doi.org/10.1530/acta.0.1050474
Abstract
Urine volume and osmolality were measured in volunteers hydrated with drinking water (2% of body wt). During maintained water diuresis, DDAVP (1-deamino-8-D-arginine vasopressin) dissolved in water was administered orally. Within 15-30 min a dose-dependent antidiuretic response occurred with a concomitant increase in urine osmolality. Administration of DDAVP through a duodenal tube caused similar antidiuretic effects indicating that the intact peptide can be absorbed from the intestinal mucosa.This publication has 6 references indexed in Scilit:
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