Specific stimulation of gastric acid secretion by a pentapeptide derivative of gastrin
- 1 October 1966
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 18 (10), 633-639
- https://doi.org/10.1111/j.2042-7158.1966.tb07776.x
Abstract
The effects of gastrin, a synthetic pentapeptide (N-t-butyloxycarbonyl-β-Ala. Try. Met. Asp. Phe. NH2; I.C.I. 50,123) and histamine on the secretion of gastric acid have been compared in a perfused stomach preparation using anaesthetised rats. The pentapeptide was shown to possess similar secretory activity to that of gastrin but to be 11 times less potent on a molar basis. It produced acid secretions similar to those produced by histamine when compared in several different ways. Unlike histamine, the pentapeptide was without significant effect on blood pressure or haematocrit in maximally stimulating doses.This publication has 6 references indexed in Scilit:
- A comparative study of the effects of gastrin, histamine, histalog, and mechothane on the secretory capacity of the human stomach in two normal subjects over 20 months.Gut, 1965
- Structure–Function Relationships in the Active C-Terminal Tetrapeptide Sequence of GastrinNature, 1965
- The antral Hormone Gastrin: Synthesis of GastrinNature, 1964
- The constitution and properties of two gastrins extracted from hog antral mucosa: Part I The isolation of two gastrins from hog antral mucosaGut, 1964
- CONTINUOUS RECORDING OF ACID GASTRIC SECRETION IN THE RATBritish Journal of Pharmacology and Chemotherapy, 1958
- Effect of Large Doses of Histamine on Gastric Secretion of HClBMJ, 1953