REGULATION OF LEISHMANIA POPULATIONS WITHIN THE HOST .3. MAPPING OF THE LOCUS CONTROLLING SUSCEPTIBILITY TO VISCERAL LEISHMANIASIS IN THE MOUSE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 37 (1), 7-14
Abstract
Acute susceptibility of the mouse to L. donovani is largely determined by a single locus designated Lsh. Linkage between the lsh locus and the chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains and was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The gene order is centromere-Lsh-Id-1-ln-Dip-l. The estimated recombination frequency between Lsh and Id-l is 0.12 .+-. 0.04. This mapping is away from the known histocompatibility loci.