Effect of Cimetidine on Tritiated Thymidine Incorporation by the Stomach, Jejunum, Colon, Liver and Spleen of Mice

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Abstract
The administration of cimetidine to mice at a dose of 200 mg/kg per 24 h inhibits the tritiated thymidine incorporation by the stomach, jejunum, colon and liver and stimulates incorporation by the spleen. These results may furnish an explanation for the rare secondary effects observed in humans. Endogenous histamine may play a role of cytohormone, regulating tissue trophicity.