Conductance fluctuations from the inactivation process of sodium channels in myelinated nerve fibres*

Abstract

Na currents and fluctuations of Na currents were studied under voltage clamp in the same myelinated nerve fibers of Rana esculenta at 13.degree. C. Several kinetic models for the gating process of Na channels were tested. All of the simple gating models considered were inconsistent with the fluctuation measurements. The coupled models gave slightly smaller deviations than the model with independent activation and inactivation.