Diacid Linkers That Promote Parallel β-Sheet Secondary Structure in Water
- 29 May 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 130 (25), 7839-7841
- https://doi.org/10.1021/ja802042c
Abstract
We report the development of diacid units that promote formation of a two-stranded parallel β-sheet secondary structure between peptide segments attached via their N-termini. These linker units are formed by attaching glycine to one carboxyl group of cis-1,2-cyclohexanedicarboxylic acid (CHDA). Parallel sheet formation in water is observed when l-residue strands are attached to the CHDA-Gly unit with either of the two absolute configurations.Keywords
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