Studies in terpenoid biosynthesis. Part X. Incorporation of (5S)-[5-3H1]mevalonic acid into gibberellic acid

Abstract

Incorporation of four 5-pro-S mevalonoid hydrogen atoms into gibberellic acid and location of two of these at C-10 and C-11 respectively has been shown by tritium labelling. The exo-9-H of methyl gibberate has been shown to exchange more rapidly than the endo-H and this has been used to demonstrate that the C(11β)-(exo) H of gibberellic acid is derived from a 5-pro-S of mevalonic acid.