Some New Developments in Reductive Amtnation with Cofactor Regeneration
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in Biocatalysis
- Vol. 10 (1-4), 37-47
- https://doi.org/10.3109/10242429409065216
Abstract
The substrate specificity of LeuDH from Bacillus stearothermophilus and of PheDH from Rhodococcus sp. was investigated and found to be complementary. LeuDH from different organisms have remarkably similar substrate specificity. During optimization of the synthesis of L-tert-leucine, two byproducts (N-α-pivaloyl-tert-leucine amide (I) and 2,4-di-tert-butyl-5-hydroxyimidazol (II)) were found and identified which originate from chemical reactions of keto acid and ammonia.This publication has 26 references indexed in Scilit:
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