Immunological Tolerance in Organ Transplantation
- 1 January 1969
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 39 (1), 5-12
- https://doi.org/10.1161/01.cir.39.1.5
Abstract
A formidable array of practical problems must be solved at laboratory level before tolerance induction in organ transplantation can be considered a realistic clinical possibility. I believe it is too early for even tentative human experimentation in this field. However, the work of the last decade has shown unequivocally that even adult animals can readily be rendered tolerant of even exceedingly powerful antigens. The principle of tolerance has such great specificity and such compelling elegance when compared with present-day aids to organ transplantation that intensive effort must go into harnessing it to clinical use. It will certainly enter the clinical homograft scene within a decade, and xenografts are inconceivable in its absence.Keywords
This publication has 11 references indexed in Scilit:
- CELL TO CELL INTERACTION IN THE IMMUNE RESPONSEThe Journal of Experimental Medicine, 1968
- ANTIGENS IN IMMUNITYThe Journal of Experimental Medicine, 1968
- The Mechanism of Immunological ParalysisAdvances in Immunology, 1968
- Focal Antibody Production by Transferred Spleen Cells in Irradiated MiceScience, 1965
- Induction of immunological paralysis in two zones of dosageProceedings of the Royal Society of London. B. Biological Sciences, 1964
- ANTIGENS IN IMMUNITYImmunology & Cell Biology, 1964
- THE LYMPHOID TISSUES AND IMMUNE RESPONSES OF NEONATALLY THYMECTOMIZED MICE BEARING THYMUS TISSUE IN MILLIPORE DIFFUSION CHAMBERSThe Journal of Experimental Medicine, 1964
- The clonal selection theory of acquired immunityPublished by Biodiversity Heritage Library ,1959
- Introductory remarksProceedings of the Royal Society of London. B. Biological Sciences, 1956
- ‘Actively Acquired Tolerance’ of Foreign CellsNature, 1953