Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis
- 1 July 1986
- journal article
- conference paper
- Published by Springer Nature in Human Genetics
- Vol. 73 (3), 267-270
- https://doi.org/10.1007/bf00401242
Abstract
Eleven families with X-linked dominant hypophosphataemic rickets (HPDR) have been typed for a series of X chromosome markers. Linkage with probe 99.6 (DXS41) was demonstrated with a peak lod score of 4.82 at 10% recombination. Multilocus linkage analysis showed that HPDR maps distal to 99.6; this probe has previously been located at Xp22.31-p21.3 by in situ hybridisation. In the mouse hypophosphataemia (Hyp) maps to the distal part of the X chromosome; our location in man is consistent with a scheme which relates the mouse and human X chromosomes by two rearrangements. No marker has yet been found which shows no recombination with HPDR.Keywords
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