Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene andtrans-stilbene oxide

Abstract

The effects of treating male Sprague-Dawley rats with phenobarbital, 3-methylcholanthrene or trans-stilbene oxide on cytosolic glutathione transferase and microsomal epoxide hydrolase activities in the liver, intestine, kidney, lung, testis, adrenal, spleen, heart and brain were investigated. Studies on the time-courses of induction in liver demonstrated that these were complete after 5 days. Phenobarbital induced cytosolic glutathione transferase and microsomal epoxide hydrolase activities significantly only in liver and intestine. 3-Methylcholanthrene induced these activities in liver only. Trans-Stilbene oxide induced both activities in liver and kidney, and cytosolic glutathione transferase activity in adrenal.