Ontogeny and Peripheralization of Thymic Lymphocytes
- 30 November 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4115), 931-933
- https://doi.org/10.1126/science.182.4115.931
Abstract
Reciprocal transplantation of undifferentiated thymic primordia between diploid and triploid chromosomally marked frog embryos has revealed that thymic lymphocytes are ontogenically derived from elements of the thymic primordium rather than from blood-borne stem cells that migrated into the developing organ. Virtually all the lymphocytes in the spleen, kidneys, and bone marrow of adult frogs are descendants of these original thymic stem lymphocytes.Keywords
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