Development and Validation of a High-Performance Liquid Chromatography Assay for Voriconazole
Open Access
- 1 July 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (7), 2348-2350
- https://doi.org/10.1128/aac.47.7.2348-2350.2003
Abstract
An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma was developed and validated. The method utilizes solid-phase extraction technology and high-performance liquid chromatography. The lower limit of quantitation is 0.2 μg/ml, and the range of linearity tested was 0.2 to 10 μg/ml.Keywords
This publication has 3 references indexed in Scilit:
- Comparison of High-Performance Liquid Chromatographic and Microbiological Methods for Determination of Voriconazole Levels in PlasmaAntimicrobial Agents and Chemotherapy, 2000
- Determination of a new antifungal agent, voriconazole, by multidimensional high-performance liquid chromatography with direct plasma injection onto a size-exclusion columnJournal of Chromatography B: Biomedical Sciences and Applications, 1997
- Analytical Methods Validation: Bioavailability, Bioequivalence, and Pharmacokinetic StudiesJournal of Pharmaceutical Sciences, 1992