URINARY EXCRETION OF PREGNANDIOL GLUCURONIDATE IN THE HYPERTENSIVE DISORDERS OF PREGNANCY*

Abstract

The excretion of pregnandiol glucuronidate was investigated in 10 pregnant [female][female] who exhibited one or another of the following hypertensive disorders: pre-eclampsia; mild, uncomplicated chronic hypertensive disease ; and severe chronic hypertensive disease complicated during gestation by the development of proteinuria. Output of this compound was abnormally low in the patients belonging to the first and last of these groups, but was unaffected in those with uncomplicated chronic hypertension. Abnormal depression of excretion was first noted at the time that proteinuria appeared, and was continuously associated with the latter phenomenon during the remainder of gestation.