Effects of Injection of 5-Adenylic Acid on Tissue Nucleotides of the Rat

Abstract

Tissue nucleotide levels (AA, ADP, ATP, and total purine) of control rats and those injd. with 5-adenylic acid were studied. At the 100 mg. injn. dose, brain, muscle, liver, and heart show significant increases in adenosine triphosphate. Of these 4 tissues, only liver exhibits a measurable increase in total purine. Kidney shows no effect. The cellular element of blood shows a small but significant increase in adenosine triphosphate, but this is accompanied by a corresponding increase in total purine. The expts. in which 5-adenylic acid, containing radioactive P is injd. into rats show a max. accumulation of the label on a wt. basis in the adrenal gland followed by liver, heart, kidney, and spleen.