REDUCED IMMUNE RESPONSIVENESS TO INTRAPORTAL ALLOGENEIC ISLETS OF LANGERHANS IN THE RAT

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Abstract
The immunological response of rats to intraportal administration of antigen, particularly pancreatic islets was investigated by quantitating cytotoxic antibody production and skin allograft survival. [Islet transplantation is useful in diabetes therapy.] Cellular antigen entering the portal circulation directly provokes a lesser immune response, both humoral and cell mediated, than the same dose administered s.c.