ALTERED OXIDATIVE METABOLIC RESPONSES INVITRO OF ALVEOLAR MACROPHAGES FROM ASYMPTOMATIC CIGARETTE SMOKERS
- 1 January 1981
- journal article
- research article
- Published by Elsevier
- Vol. 123 (1), 85-89
- https://doi.org/10.1164/arrd.1981.123.1.85
Abstract
Superoxide anion .**GRAPHIC**. released by alveolar macrophages (AM) from young asymptomatic cigarette smokers was greater than that by AM from age-matched nonsmokers. Greater .**GRAPHIC**. release by AM from cigarette smokers was observed before and after stimulation by bacteria or phorbol myristate acetate (PMA). O2 uptake and glucose (1-14C) oxidation by unstimulated or stimulated AM from cigarette smokers was the same as that by AM from nonsmokers. Selective increase of .**GRAPHIC**. release by AM from cigarette smokers was not due to a lack of .**GRAPHIC**. scavenging agent within cells, since intracellular superoxide dismutase (SOD) was increased in AM from smokers. The potential importance of enchanced .**GRAPHIC**. release by AM from cigarette smokers was confirmed by demonstrating that lysis of fibroblasts induced by AM from smokers was completely prevented by addition of SOD and catalase.This publication has 19 references indexed in Scilit:
- The Relations between Structural Changes in Small Airways and Pulmonary-Function TestsNew England Journal of Medicine, 1978
- Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.JCI Insight, 1978
- Human Alveolar Macrophage Proteolytic Enzyme Activities in Chronic Obstructive Pulmonary DiseaseChest, 1978
- Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen.Journal of Biological Chemistry, 1977
- Elastase Release from Human Alveolar Macrophages: Comparison Between Smokers and NonsmokersScience, 1977
- Superoxide dismutase and peroxidase: A positive activity stain applicable to polyacrylamide gel electropherogramsArchives of Biochemistry and Biophysics, 1977
- Influence of a deficiency of the second component of complement on the bactericidal activity of neutrophils in vitro.JCI Insight, 1977
- STIMULATION OF HEXOSE MONOPHOSPHATE SHUNT INDEPENDENT OF HYDROGEN-PEROXIDE AND SUPEROXIDE PRODUCTION IN RABBIT ALVEOLAR MACROPHAGES DURING PHAGOCYTOSIS1977
- The alteration of superoxide dismutase, catalase, glutathione peroxidase, and NAD(P)H cytochrome c reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hyperoxia.JCI Insight, 1976
- HISTOCHEMICAL STUDIES OF LYSOSOMES AND LYSOSOMAL ENZYMES IN VIRUS-INFECTED CELL CULTURESThe Journal of Experimental Medicine, 1965