Screening of a combinatorial steroid library using molecularly imprinted polymers

Abstract

Molecular imprinting is an attractive method for producing highly selective adsorbents, and several new and potentially useful applications based on molecularly imprinted polymers (MIPs) have been described in recent years. In this article, we introduce a new field of application in which the selectivities of imprinted materials can be gainfully employed as binding matrices in the screening of combinatorial libraries. MIPs prepared against androstenone structures could be efficiently employed to select these compounds from a combinatorial library.