Tolerance to the hypothermic effects of Δ9‐tetrahydrocannabinol as a function of age in the chicken

Abstract

1 (—)-Δ⁹-Tetrahydrocannabinol was administered to chicks (Gallus domesticus) of various ages and body temperature and tolerance to the hypothermic effects of the drug were examined as a function of age. 2 The hypothermic effects were found to be greater in neonatal than older animals and likewise tolerance took longer to develop in younger chicks. 3 The rate of tolerance development, however, could be increased in the neonate by preadministration of a high dose of the drug.