DYSFUNCTION OF NATURAL-KILLER CELLS IN MULTIPLE-SCLEROSIS - A POSSIBLE PATHOGENETIC FACTOR
- 1 January 1980
- journal article
- research article
- Vol. 39 (3), 657-662
Abstract
Natural killer (NK) cell activity, antibody-dependent cytotoxicity (ADCC) and the effect of interferon on NK activity was investigated in multiple sclerosis (MS) patients. NK activity measured against K-562 [myeloid] tumor cell line was significantly low in MS patients, and this was most pronounced in the group of male patients with definitive disease. The response of NK cells to interferon proved to be impaired, and almost no activation could be demonstrated in response to polyinosinic-polycytidylic acid (poly I:C). Preliminary data obtained by the determination of interferon production in several definitive MS cases reflect a defect in the interferon producing capacity of lymphocytes. The possible involvement of impaired NK cell function in the etiopathogenesis of MS is discussed.This publication has 22 references indexed in Scilit:
- MEASLES VIRUS IN JEJUNUM OF PATIENTS WITH MULTIPLE SCLEROSISThe Lancet, 1979
- Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicityNature, 1979
- Enhanced NK cell activity in mice injected with interferon and interferon inducersNature, 1978
- Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.The Journal of Experimental Medicine, 1978
- Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation.The Journal of Experimental Medicine, 1978
- Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in miceNature, 1977
- BLOOD-FLOW IN INCOMPETENT PERFORATING VEINSThe Lancet, 1977
- HL-A 3,7 AND LYMPHOCYTE CYTOTOXIC ACTIVITYThe Lancet, 1974
- ASSOCIATION BETWEEN HL-A ANTIGENS AND MEASLES ANTIBODY IN MULTIPLE SCLEROSISThe Lancet, 1973
- MEASLES ANTIBODY IN SERUM OF MULTIPLE SCLEROSIS PATIENTS, THEIR CHILDREN, SIBLINGS AND PARENTSActa Neurologica Scandinavica, 1972