Chromosomal Abnormalities in Spleens of New Zealand Black Mice, A Strain Characterized by Autoimmunity and Malignancy
- 1 April 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (4), 1094-1098
- https://doi.org/10.1073/pnas.70.4.1094
Abstract
Mosaicism of normal and chromosomally aberrant cells was detected in 14 of 20 spleens from adult New Zealand Black (NZB) mice reared under conventional conditions, a strain that spontaneously develops autoimmunity and lymphoreticular malignancy. No abnormalities were found in marrows from these same animals or in spleens from NZB mice younger than 3 months. The prevalence of chromosomal aberrations was significantly higher in spleens from NZB mice than in spleens from the two other strains studied-SJL/J, which has high frequency of reticulum cell neoplasia and paraproteinemia but no autoimmunity, and BALB/c, which has essentially no autoimmunity and only a low incidence of generalized lymphoid neoplasms and plasmacytomas in ageing animals. Causes for the chromosomal abnormalities in NZB mice are considered in terms of other features in these mice-immunoproliferation, autoimmunity, and the presence of murine leukemia ("C"-type) virus particles.Keywords
This publication has 15 references indexed in Scilit:
- Response of NZB and NZB/NZW Spleen Cells to Mitogenic AgentsThe Journal of Immunology, 1970
- SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSEThe Journal of Experimental Medicine, 1970
- Autoimmune reactions and malignant changes in germ-free New Zealand Black mice.1969
- Deficient Immunologic Functions of NZB MiceExperimental Biology and Medicine, 1968
- RETICULUM CELL NEOPLASM TYPE B OR HODGKINS-LIKE LESION OF MOUSE1968
- Abnormal Serum Immunoglobulins Occurring With Reticular Neoplasms in an Inbred Strain of MouseJNCI Journal of the National Cancer Institute, 1967
- "Immunologic" oncogenesis.1967
- Paraproteinemia and Reticulum Cell Sarcoma in an Inbred Mouse StrainScience, 1966
- Malignant Lymphomas Following Allogenic Disease: Transition from an Immunological to a Neoplastic DisorderScience, 1965
- AUTOIMMUNITY: A PREDISPOSING FACTOR TO CHROMOSOMAL ABERRATIONS?The Lancet, 1964