Further Observations on Hyponatremia and Renal Sodium Loss Probably Resulting from Inappropriate Secretion of Antidiuretic Hormone

Abstract

IN a previous report¹ metabolic studies were presented on 2 patients with bronchogenic carcinoma and normal renal and adrenal function, who were found to have severe hyponatremia with renal sodium loss. The urine was persistently hypertonic to the serum, and contraction of body-fluid volume did not occur as sodium depletion and hypotonicity of the serum progressed. As an explanation for these findings, it was postulated that the underlying process induced a sustained, inappropriate secretion of antidiuretic hormone and that the syndrome was a consequence of the resulting expansion of body-fluid volume.This paper presents metabolic studies in a third patient . . .