Oxygen-induced retinopathy: ultrastructure of vitreous new vessels in the kitten model
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Current Eye Research
- Vol. 9 (8), 741-748
- https://doi.org/10.3109/02713689008999569
Abstract
Oxygen-induced retinopathy was produced by exposing 3-day-old kittens to 80% oxyen between 60 and 105 hours. They were then allowed to survive in room air until day 15, 21 or 28 when they were sacrificed after perfusion with colloidal carbon. Specimens were prepared for transmission electron microscopy. Ninety separate vitreous capillaries from oxygen-treated animals were examined. A total of 235 intercellular junctions were examined, 116 of them from the 15-day old animals. In the 15-day old animals, five junctions of 116 were open and the remainder were tight. No open junctions were seen in 21- or 28-day-old animals. In one capillary from a 15-day animal, fenestrated endothelium was seen in an aberrant, intraluminal loop of endothelium which formed no part of the blood/tissue barrier. The wall thickness of the vitreous new vessels seemed to decrease and the number of vesicles and vacuoles appeared to increase with increasing age. The basement membrane of the vitreous new vessels was scant. In some sections, cells, presumably macrophages, were seen outside the new vessels. It is concluded that the increased permeability of the vitreous new vessels in 15-day-old animals can be explained by, and is possibly totally due to, the presence of open endothelial junctions.This publication has 13 references indexed in Scilit:
- Subretinal Neovascularization After Experimental Ocular Histoplasmosis in a Subhuman PrimateAmerican Journal of Ophthalmology, 1985
- OXYGEN INDUCED RETINOPATHY: THE KITTEN MODEL RE–EXAMINEDAustralian and New Zealand Journal of Ophthalmology, 1982
- ENDOTHELIAL FENESTRAE IN PROLIFERATIVE DIABETIC-RETINOPATHY1980
- The passage of macromolecules across inflamed capillary endothelium via large vacuolesMicrovascular Research, 1979
- Ultrastructure of Epiretinal Membrane Removed by Pars Plana Vitreoretinal SurgeryAmerican Journal of Ophthalmology, 1977
- An electron microscopic study of hyalocytesExperimental Eye Research, 1965
- Studies on the structure of the vitreous bodyExperimental Eye Research, 1964
- Studies on inflammationVirchows Archiv, 1963
- THE PERMEABILITY OF BLOOD CAPILLARY SPROUTS AND NEWLY FORMED BLOOD CAPILLARIES AS COMPARED TO THAT OF OLDER BLOOD CAPILLARIESAmerican Journal of Physiology-Legacy Content, 1946