THE MECHANISM OF THE VIRUCIDAL ACTION OF ASCORBIC ACID
- 8 June 1945
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 101 (2632), 587-589
- https://doi.org/10.1126/science.101.2632.587
Abstract
The theoretical yield of H2O2 formed during the oxidation of a virucidal solution of ascorbic acid approximates the virucidal action of an equivalent amount of H2O2. Both the action of ascorbic acid and H2O2 are completely neutralized by catalase. The action of ascorbic acid against influence A virus may therefore be explained as being due to the H2O2 formed during the Cu catalyzed oxidation of ascorbic acid. The observed in vitro virucidal activity of ascorbic acid obviously can not be utilized therapeutically because of the presence of catalase in body tissues.This publication has 3 references indexed in Scilit:
- THE EFFECT OF SOME CHEMICALS ON PURIFIED INFLUENZA VIRUSThe Journal of Experimental Medicine, 1944
- CONSTITUENTS OF ELEMENTARY BODIES OF VACCINIAThe Journal of Experimental Medicine, 1941
- INACTIVATION OF POLIOMYELITIS VIRUS IN VITRO BY CRYSTALLINE VITAMIN C (ASCORBIC ACID)The Journal of Experimental Medicine, 1935