Glucose vs Sucrose in Oral Rehydration Solutions for Infants and Young Children with Rotavirus-Associated Diarrhea
- 1 January 1981
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 67 (1), 79-83
- https://doi.org/10.1542/peds.67.1.79
Abstract
The use of oral rehydration solutions containing essential electrolytes and either glucose or sucrose of equal osmolality was compared in a double-blind sequential trial of 784 children with rotavirus-associated diarrhea treated at a center in rural Bangladesh. The oral fluid failure rate was 11.5% for the sucrose-containing solution group and 7.3% for the glucose-containing group (P = not significant). Vomiting was a significantly more common cause of failure for the group treated with sucrose-containing oral rehydration solution and was associated with an increased rate of intake of the sweeter sucrose-containing solution. The purging rate was not different for the 2 groups. The oral fluid failure rates for children in the most underweight category (< 60% of expected weight for age) were not different from those for other groups, although, as assessed by purging rate and initial dehydration, the stool losses of members of this group constituted a greater proportion of their body weight. Glucose is the preferred carbohydrate for oral electrolyte solutions, but sucrose can be substituted with only minimum loss of efficacy.This publication has 8 references indexed in Scilit:
- Oral rehydration therapy for treatment of rotavirus diarrhoea in a rural treatment centre in Bangladesh.Archives of Disease in Childhood, 1980
- Oral therapy in children with cholera: A comparison of sucrose and glucose electrolyte solutionsThe Journal of Pediatrics, 1980
- Analysis of nonspecific reactions in enzyme-linked immunosorbent assay testing for human rotavirusJournal of Clinical Microbiology, 1979
- Use of colony pools for diagnosis of enterotoxigenic Escherichia coli diarrheaJournal of Clinical Microbiology, 1979
- ORAL HYDRATION IN ROTAVIRUS DIARRHŒA: A DOUBLE BLIND COMPARISON OF SUCROSE WITH GLUCOSE ELECTROLYTE SOLUTIONThe Lancet, 1978
- COMPARISON OF SUCROSE WITH GLUCOSE IN ORAL THERAPY OF INFANT DIARRHŒAThe Lancet, 1978
- ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) FOR DETECTION OF HUMAN REOVIRUS-LIKE AGENT OF INFANTILE GASTROENTERITISThe Lancet, 1977
- EVALUATION OF A SUCROSE/ELECTROLYTE SOLUTION FOR ORAL REHYDRATION IN ACUTE INFANTILE DIARRHŒAThe Lancet, 1977