Cellular hypersensitivity in attacks of multiple sclerosis
- 31 January 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 27 (2), 132
- https://doi.org/10.1212/wnl.27.2.132
Abstract
Although cell-mediated hypersensitivity to basic myelin protein has been demonstrated in multiple sclerosis with use of cell migration assays, results with the lymphoblastic transformation technique have been inconclusive. However, prospective studies relating results of lymphoblastic transformation to the clinical course of multiple sclerosis have not been reported. In the present study, both lymphoblastic transformation and migration inhibitory factor assays were used, and results related to the temporal course of multiple sclerosis. Results of the present investigation show that cell-mediated hypersensitivity to myelin basic A1 protein is most significant during exacerbations of multiple sclerosis. Responses obtained employing either the lymphoblastic transformation or migration inhibitory factor assay were equally significant. The results support the hypothesis that a factor suppressing deoxyribonucleic acid synthesis is present in multiple sclerosis and is inhibited by the use of steroids.This publication has 3 references indexed in Scilit:
- AN ENCEPHALITOGENIC PROTEIN OF HUMAN ORIGIN; SOME CHEMICAL AND BIOLOGICAL PROPERTIES*Annals of the New York Academy of Sciences, 1965
- DELAYED HYPERSENSITIVITY IN VITRO .I. SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS1964
- In vitro Cell Migration as a Model for Delayed Hypersensitivity.Experimental Biology and Medicine, 1962