A simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in plasma by gas liquid chromatography
- 1 June 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (6), 425-429
- https://doi.org/10.1111/j.2042-7158.1975.tb09472.x
Abstract
A novel method for the simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in biological fluids by gas liquid chromatography is described. The assay has been used to determine the plasma concentration of salicylates in 10 volunteers after oral ingestion of three commercially available aspirin-containing formulations. No difficulty was encountered in determining low concentrations of acetylsalicylic acid in the presence of higher concentrations of salicylic acid. The in vivo plasma half life of acetylsalicylic acid in man was found to be 15.5 min.Keywords
This publication has 15 references indexed in Scilit:
- GLC Analysis of Aspirin from Solid Dosage FormsJournal of Pharmaceutical Sciences, 1972
- Plasma and synovial fluid concentrations of acetylsalicylic acid in patients with rheumatoid arthritisArthritis & Rheumatism, 1967
- Determination of acetylsalicylic acid and salicylic acid in plasmaJournal of Pharmaceutical Sciences, 1967
- Acetylsalicylic acid hydrolysis in human blood and plasma I. Methodology and in vitro studiesJournal of Pharmaceutical Sciences, 1967
- ASPIRINAnesthesia & Analgesia, 1965
- Evaluation of Acetylsalicylic Acid Esterase in Aspirin MetabolismJournal of Pharmaceutical Sciences, 1965
- Gas Chromatographic Determination of Acetylsalicylic Acid.Analytical Chemistry, 1964
- The influence of solubility on the rate of gastrointestinal absorption of aspirinClinical Pharmacology & Therapeutics, 1963
- Presence of Acetylsalicylic Acid in Plasma Following Oral Ingestion of AspirinExperimental Biology and Medicine, 1962
- Salicylamide I. Absorption, Excretion, and Blood LevelsJournal of the American Pharmaceutical Association (Scientific ed.), 1954