Progestins and Skeletal Maturation

Abstract

THE association of virilization of the female fetus with the administration of certain progestins during pregnancy is now well recognized. Since Wilkins et al.¹ first called attention to this matter other reports have appeared and have incriminated, although rarely, some estrogenic compounds as well.² This brief report concerns 6 infants referred to this service because of masculinization of the genitalia. In addition to these changes 5 of the 6 patients were found to have significant advancement of bone maturation.Six female infants, four days to thirty months of age, with varying degrees of clitoral enlargement and labioscrotal fusion due to . . .