Effects of prenatal administration of hadacidin, a cancer chemotherapeutic agent, on the development of hamster fetuses
Open Access
- 1 June 1977
- journal article
- research article
- Published by The Company of Biologists in Development
- Vol. 39 (1), 203-220
- https://doi.org/10.1242/dev.39.1.203
Abstract
A single intraperitoneal injection of 1−2·5 g/kg body weight of hadacidin was teratogenic when administered to pregnant hamsters between days 8 and 11 of gestation. Both the frequency of malformation and resorption were related to the dose and time of hadacidin administration. The drug produced both gross and microscopic malformation in the fetus and impaired its general growth. The malformation involved craniofacial structures, central nervous system, respiratory, digestive and urinary systems, limbs and tail. Morphologically different types of cleft lip and cleft palate were related to the dose and time of hadacidin treatment. An association was observed between cleft lip, cleft palate and micrognathia on one hand, and between cleft palate and micrognathia on the other. Significance of association between the lip, the palate and the mandibular malformation was discussed and the hypothesis that human cases of Pierre Robin syndrome may result from an environmental assault was supported. It was suggested that the fetal weight and the microscopic analysis should be included in the criteria for the teratological drug safety evaluation procedures.This publication has 41 references indexed in Scilit:
- Etiology and pathogenesis of congenital cleft lip and cleft palate, an NIDR state of the art reportTeratology, 1972
- Minor congenital defects in children of low birth weightThe Journal of Pediatrics, 1972
- The Analysis of Multidimensional Contingency Tables: Stepwise Procedures and Direct Estimation Methods for Building Models for Multiple ClassificationsTechnometrics, 1971
- Intra-Uterine Growth Retardation in the Pig. I. Organ Size and Cellular Development at Birth and after Growth to MaturityNeonatology, 1971
- Malnutrition and brain developmentThe Journal of Pediatrics, 1969
- An analysis of the growth retarding effects of trypan blue in the albino ratsThe Anatomical Record, 1967
- The pathogenesis of cleft palate. An animal studyBritish Journal of Surgery, 1965
- The Teratogenic Effect of the Steroid Nucleus in the RatJournal of Dental Research, 1964
- Teratogenic effect of Hadacidin (a new growth inhibitory chemical) on the rat fetusJournal of Experimental Zoology, 1963
- Congenital hypoplasia of the mandibleThe Journal of Pediatrics, 1940