Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Open Access
- 1 June 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 339 (6224), 439-445
- https://doi.org/10.1038/339439a0
Abstract
The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.Keywords
This publication has 49 references indexed in Scilit:
- Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulumNature, 1989
- Sequence and Expression of mRNAs Encoding the α 1 and α 2 Subunits of a DHP-Sensitive Calcium ChannelScience, 1988
- Ultrastructure of the calcium release channel of sarcoplasmic reticulum.The Journal of cell biology, 1988
- Conserved organization of the human and murine T-cell receptor β-gene familiesNature, 1988
- Purified ryanodine receptor of skeletal muscle sarcoplasmic reticulum forms Ca2+-activated oligomeric Ca2+ channels in planar bilayers.Proceedings of the National Academy of Sciences, 1988
- Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAsNucleic Acids Research, 1984
- Organization and Expression of Eucaryotic Split Genes Coding for ProteinsAnnual Review of Biochemistry, 1981
- Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybridsCell, 1977
- Calcium release from the sarcoplasmic reticulumPhysiological Reviews, 1977
- STUDIES OF THE TRIADThe Journal of cell biology, 1970