Content of a cross‐reactive idiotype in nonimmune A/J sera

Abstract

The anti‐p‐azophenylarsonate antibodies of A/J mice express a major intrastrain cross‐reactive idiotype (CRI_A). Using a sensitive radioimmunoassay we were unable to detect significant quantities of molecules bearing CRI_A in nonimmune A/J sera. The upper limit is 140 ng/ml. Possible reasons for variability of such data in the published literature are discussed.