S-adenosylmethionine levels in psychiatric and neurological disorders: a review
- 1 May 1994
- journal article
- review article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 89 (S154), 19-26
- https://doi.org/10.1111/j.1600-0404.1994.tb05405.x
Abstract
S-adenosylmethionine (SAMe) is an important methyl donor in over 35 methylation reactions involving DNA, proteins, phospholipids and catechol- and indole- amines. This article reviews the studies that have examined brain and blood levels of SAMe in several psychological, neurological and metabolic disorders. Although studies have found no consistent changes in whole blood SAMe levels in psychiatric patients, other investigators have found low cerebrospinal fluid (CSF) SAMe levels in patients with neurological disorders such as Alzheimer's dementia, subacute combined degeneration of the spinal cord (SACD), and HIV-related neuropathies, as well as in patients with metabolic disorders such as 5, 10-CH2-H4 folate reductase deficiency. Intravenous or oral administration of SAMe thus represents a possible treatment for these neurological and metabolic disorders.Keywords
This publication has 45 references indexed in Scilit:
- Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in down's syndrome, AIDS and Alzheimer's disease?Medical Hypotheses, 1992
- Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patientsThe Lancet, 1991
- Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.Journal of Neurology, Neurosurgery & Psychiatry, 1990
- Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: Cerebrospinal fluid S-adenosylmethionine declines with age in humansBiochemical Medicine and Metabolic Biology, 1990
- S-Adenosyl-L-MethionineDrugs, 1989
- Subacute combined degeneration of the cord due to folate deficiency: response to methyl folate treatment.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Medication Effects on One-Carbon Metabolism inJournal of Clinical Psychopharmacology, 1986
- The transmethylation and one-carbon cycle hypotheses of schizophreniaPsychological Medicine, 1983
- Cobalamin inactivation by nitrous oxide produces severe neurological impairment in fruit bats : Protection by methionine and aggravation by folatesLife Sciences, 1982
- Differential activation of rat liver methionine adenosyltransferase isozymes by dimethylsulfoxideBiochemical and Biophysical Research Communications, 1977