There is no known specific treatment for sarcoidosis. The present report is concerned with the successful use of intramuscularly administered cortisone in a case of generalized sarcoidosis with extensive and severe bilateral ocular involvement. The patient's vision had deteriorated steadily over a seven months' period in spite of conventional therapy at two ophthalmological institutions, and when she presented herself for admission to Montefiore Hospital she was almost blind. From the first day of treatment the patient's vision improved, and when cortisone therapy was discontinued she had 76% of normal binocular vision and was able to resume all her usual daily activities. Of further interest was the substantial shrinkage of enlarged mediastinal nodes, which occurred during the first month of cortisone therapy and was still sustained six months after therapy has been discontinued. REPORT OF A CASE P. D., a Negro housewife aged 30, was admitted to the ophthalmological service of