New method of linking tryptophan to cysteine sulphydryl groups in peptides and proteins
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 600-601
- https://doi.org/10.1039/c39760000600
Abstract
A new simple method for establishing a crosslink between tryptophan and cysteine leading to tryptathionine (1), involving the reaction of 3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid (2) with cysteine in 25% trifluoroacetic acid, is described.This publication has 1 reference indexed in Scilit:
- [40] Sulfenyl halides as modifying reagents for polypeptides and proteinsMethods in Enzymology, 1972