Abstract
Application of electrical pulses to guinea pig cerebral slices metabolizing radioactive phosphate results in an increase in activity of the phosphoprotein phosphorus. No other group of tissue components insoluble in trichloroacetic acid showed such a change. The change occurred within 10 seconds and proceeded at a minimal rate of 400 u moles/g wet weight of tissue/hour. The results are discussed in relation to cerebral phosphoprotein metabolism.