Isoarecolone-induced enhancement of delayed matching to sample performance in monkeys: role of nicotinic receptors
- 1 May 1995
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 6 (8), 1223-1227
- https://doi.org/10.1097/00001756-199505300-00037
Abstract
Nicotine enhances memory performance in young and aged monkeys performing a version of the delayed matching to sample (DMTS) task. However, the beneficial actions of nicotine are often limited by debilitating side effects. Isoarecolone is a piperidine derivative with nicotine-like activity, but having a slightly different profile of behavioral actions in rodents. In young monkeys, isoarecolone produced a dose-dependent enhancement of the DMTS task on the same day of testing, with a trend towards enhanced performance in animals tested 24 h after administration. Isoarecolone was about 1500-fold less potent than nicotine in enhancing DMTS performance. The ability of isoarecolone to enhance DMTS performance was well correlated with its ability to interact with cortical nicotinic receptorsin vitro.Keywords
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