Interactions among iron(II) bleomycin, Lewis bases, and DNA.
- 1 December 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (12), 7517-7520
- https://doi.org/10.1073/pnas.78.12.7517
Abstract
The interaction of S-containing ligands with complexes of Fe(II) bleomycin [Fe(II)Blm] [an antitumor agent] was investigated by comparing DNA [synthetic] strand-scission activity with the structural characteristics of the complex. The bithiazole ring of excess Blm can form intermolecular complexes with Fe(II)Blm and with NO-Fe(II)Blm and the bithiazole groups of CO-Fe(II)Blm interact with the metal center. This binding can be reversed by glutathione. CO-Fe(II)Blm binds to poly(dA-dT).cntdot.poly(dA-dT) via its bithiazole group to change the environment of the Fe2+ ion. Glutathione binds to the CO-Fe(II)Blm-poly(dA-dT).cntdot.poly(dA-dT) complex under conditions in which it stimulates DNA strand scission by Fe(II)Blm.This publication has 17 references indexed in Scilit:
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