Studies on 1-alkyl-2(1H)-pyridone derivatives. XXX Reactions of 1-alkyl-2(1H)-pyridones with fumaric acid monomethyl ester and acrylic acid.

Abstract

Studies aimed at the synthesis of 6-azabicyclo [3.2.1] octane derivatives from 1-alkyl-2 (1H) -pyridones (Ia-d) were carried out. Reactions of Ia-d with fumaric acid monomethyl ester and acrylic acid gave 6-alkyl-8-endo-methoxycarbonyl-7-oxo-6-azabicyclo [3.2.1] oct-2-ene-2-carboxylic acids (VIIa-d) and 6-alkyl-7-oxo-6-azabicyclo [3.2.1] oct-2-ene-2-carboxylic acids (Xa-d), respectively.