Relationship of postprandial serum gastrin response to sex, body weight, blood group status, familial dyspepsia, duration, and age of onset of ulcer symptoms in duodenal ulcer.
Open Access
- 1 June 1980
- Vol. 21 (6), 528-532
- https://doi.org/10.1136/gut.21.6.528
Abstract
Integrated postprandial serum gastrin levels were studied in a prospective series of 144 Chinese patients with duodenal ulcer in relation to sex, total body weight, age of onset and duration of ulcer symptoms, blood group status, and positivity for familial dyspepsia. Postprandial gastrin was unrelated to sex, total body weight, duration of symptoms, and blood group status. Patients whose onset age was in the first two decades (early onset group) had significantly higher postprandial gastrin than those with onset age in the 4th and 6th decades (P less than 0.01). This was found to be associated with the presence in the early onset group (n = 35) of a high proportion of patients with positive family history of ulcer dyspepsia (n = 24), in whom postprandial gastrin was significantly higher than those without such history (P less than 0.01). These results suggest that early onset patients who are positive for family history of ulcer dyspepsia segregate to form one subgroup of duodenal ulcer. They also offer a clue that familial hypergastrinaemia may be one marker for familial duodenal ulcer.Keywords
This publication has 30 references indexed in Scilit:
- Peptic Ulcer Disease-A Heterogeneous Group of Disorders?Gastroenterology, 1977
- Failure to confirm evidence for existence of two populations with duodenal ulcer.BMJ, 1976
- GastrinNew England Journal of Medicine, 1975
- Duodenal Ulcer in ChildrenArchives of Disease in Childhood, 1972
- Peptic ulcer in adolescents. Clinical study.1971
- Hydrochloric acid secretion capacity of the stomach as an inherited factor in the pathogenesis of duodenal ulcerDigestive Diseases and Sciences, 1968
- Clinical data and characteristics differentiating types of peptic ulcer.Gut, 1968
- Duodenal ulceration in childrenGut, 1965
- PEPTIC ULCERATION AND ABO BLOOD GROUPSJAMA, 1956
- Heredity and peptic ulcer.1950